Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethyl pentanoate in a murine model of invasive aspergillosis.

نویسندگان

  • Rajesh Dabur
  • S K Diwedi
  • V Yadav
  • V Mishra
  • Rambir Singh
  • H Singh
  • G L Sharma
چکیده

2-(3,4-Dimethyl-2,5-dihydro-1H-pyrrole-2-yl)-1-methylethyl pentanoate, an antifungal compound, was found to be nontoxic to RAW cells up to a concentration of 312.5 microg/ml, whereas amphotericin B was lethal to all cells at 37.5 microg/ml. The treatment of Aspergillus fumigatus-infected mice with a dose of 200.0 mg of compound/kg of body weight increased their survival rate by 60%, with a decrease in CFU in organ tissues. The protection afforded by the compound against experimental aspergillosis was found to be dose dependent.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 49 10  شماره 

صفحات  -

تاریخ انتشار 2005